I will just say this, there is ZERO magic caliber that kills deer dead right there ALL the time

things can happen and deer can run off

I have seen (we even had it on video) a small doe (she was feeding ina food plot NOT spooked or on alert too) shot at less than a 100 yards thru the lungs and heart with a 50 BMG 750 grain soft point, 13,000 FT Lbs of energy, a hole thru is a person could throw a foot ball thru and NOT hit anything part of the deer! yet that deer ran almost a 100 yards HOW?? who know's , as all vitals were pretty much GONE shoulder bones broke as well,

and I have seen others deer run after being hit with several other VERY large, over kill, calibers for deer,
shot in the vitals(heart lungs)

IMO< sometimes < they can be dead on there feet and still run!