Man, this question is like asking someone if they like Chevy, Ford, or Dodge. It really just depends on what you are confortable with. Myself, I hunt in the Texas Hill Country. I like shooting small calibers like the 22-250. Now I don't recomend that just anybody use this caliber because shot placement is critical. If you plan to shoot your deer in the body then a larger caliber is needed like 25-06, .270, 30-06 or something along those lines. I shoot all my deer in the neck so the 22-250 is ideal. I wouldn't hesitate to shoot a large mule deer in the neck with this caliber. Point in case, I killed a 230lb Audad last year with one shot in the neck with my 22-250. It really is preference and what you feel confortable with.