If it was for only heavy dangerous game such as elephant, cape buffalo, or hippo I would use a 458 caliber rifle, if it was for cats it would be 375 caliber rifle. Many like the 416's as an all-around DG rifle and I would not disagree with that choice.

I think the CZ is a good choice if you have a little work done to them by a specialist (trigger, safety, perhaps feeding if needed). They are solidly built, reliable, and there are many guys that like them for the largest cartridges. However, I understand they are discontinuing production. Another good choice would be the M70 Safari Express, which is solidly built, reliable, and needs no work.

I shoot the 375's well and the recoil does not keep me off target long. The 458 Win and the 458 Lott are harder to get that second shot off accurately but definitely punch harder. I have used a Lott for game even as light as eland, but I think the 458 Winchester does the same job with a little less fuss and the 416's work just as well. Frankly shooting much from 458 or 470 rifles literally gives me a headache.