Jake did you get one yet? I used to have a Taurus tcp. I believe the model was a 748 and it was in .380. I fed it Critical Defense ammo and although I literally did carry it in my pocket it did come with a wallet type holster. I would take it out and brush the pocket lint off it every once in a while. But before I did I loaded up the extra mag with 380 .roundball ammo and fired it off. Never any jams or failure to fire with either ammo and it was surprisingly accurate (to about the 10-15 feet I shot it!). It was indeed a close range weapon but IMO reliable.
I have big hands also but I could shoot it without any difficulty