In the latter stages of CWD. the animal will be thin and look rough. In the earlies stages there may not be much for sighns of the deasease. There has been no proven cases that eating the meat can spread the dease to humans. There is however no proof that it cannot be. I always wear gloves but mostly to make cleaning my hands and arms easier. I would not be afraid at all of eating the meat from a healthy looking deer. CWD has been found in most states but to a lesser degree in some than others. Much depends on how many deer the test. Some states don't want to find it so they don't test as many deer. There is quite a bit of info online about CWD. Do a search.