Don't know if you were talking to me, hardcast, but I'm very confident shooting my .44 magnum revolver well past 50 yards, if sighted in. Problem is, I typically don't sight it in for those distances. Also, the hollowpoints I normally use have a much lower trajectory than the Buffalo Bores I carry for bear backup. My worry is that I would miss a bear at 50 yards due to this lack of sighting.
In contrast, I typically put about 100-200 rounds through each of my hunting rifles every spring/summer in preparation for bear season. Not that it will ever happen here, but I wouldn't hesitate to shoot a bear past 300 yards with any of my hunting rifles.