What is your ultimate goal for this rifle? Is it for target shooting or for hunting? For target shooting my .45's seem to like 55 grains of 3f with a .445 ball and a .015 mink oil lubed patch. Both guns ar 1:48" twist, and i get 1" or less groups from the bench with this load. I have never hunted with a .45, but i did work up a load that shoots the .440 ball with .015 mink oil lubed patch and 75 grains of 3f that shot 1.5" groups at 50 yards and about 2.5" at 75 yards. I do not shoot game much beyond 60 yards as my personal limit due to trouble seeing the iron sights. I have friends that use the 45 for deer hunting, they are picky about their shots, but they have taken quite a few deer at over 50 yards and never recovered a ball.