In my younger days, I carried a custom Sako 375 H&H, and it was used for everything from gophers to moose. I still feel that it is an excellent choice for everything on this planet. After I broke my back, I went to a 300 Mag. Back issues dictated that it was too much for me. I then went to the 270 Weatherby magnum. Super cartridge that served me well for a lot of years. Again, my back told me don't shoot it any more. I went to the 25 06, and have used it on everything, with excellent results, and no back issues. It isn't displacement, it's placement that puts your meat on the table. The only reason that I used the big bores, was that I hunted the mountains exclusively in grizzly country. A 25 06 with a 120 grain bullet will drop an elk with authority. I surely miss my heavies, but in reality, in most situations, they are not needed. I sold everything from 458 Winchester mag on down. If I can't shoot and enjoy them, I don't want them. I truly miss my Weatherbys, but in reality, they aren't needed for most of the hunting situations. I never seen any difference in the level of dead on an elk whether I shot it with a 340 or a 25 06.