The bullets used have a lot to do with the effectiveness of a cartridge...Back in the late '60s I used a 22-250 to kill dozens of deer that were eating our peanuts and soybeans...These were 55gr fast expanding bullets made for things like groundhogs...In 1980, I bought a .243 and used it for over 30 years on deer, I realized I got much better results and blood trails...
Now, fast forward to the present...The military uses non expanding bullets...You can get 60gr bullets in .22 caliber like Nosler Partitions for the .223 and 22-250...About 10 years ago, my youngest brother picked up a 22-250 in a trade, he called me to set the rifle up for his daughter to deer hunt with...I bought a couple of boxes of the 60gr Nosler Partions and she has proceeded to kill dozens of deer with that gun...A .223 with the same bullet, put in the right place would do the same...Selecting the proper bullet for the game is very important in these two calibers...