My sister uses 220gr Lehigh .458 Controlled Fracturing stuffed down in Harvester crushed rib. She's been using that combo for a little bit now and 6 deer later I can tell you there has been no need of a blood trail. Only one of those 6 took a step and it was just a few with it's nose in the dirt. But they did all have a pass through with the back portion of the bullet that doesn't fracture off and blood everywhere. I used them sabotless in my smokeless and dropped a couple of Caribou and they performed flawlessly. I would go over to Lehighs site and order up whatever CF muzzleloading bullet they have that you think will fit your Omega and give some a test run. They aren't target bullets but out to 200, Alex hits my 6 inch gong with alarming regularity. And that's with a little TC impact with that combo sitting on top of 90gr BH. Those .458's are a tad tight to start but BH likes a tight fit anyway.
https://www.lehighdefense.com/collections/muzzleloader They don't have those 220gr 458's that Tom sent her a ton of but they do have the 230's, 240's and 265's in .451 and .452. You could also try out the Bloodlines. Same maker, same bullets just branded by Knight. Several folks around here use them and love them.