It' s been my experience that most rifles like a couple of fouling shots to get them back on track after cleaning. I only have one rifle that hits zero with the first shot after cleaning and it' s a Sendero. My other rifles tend to be a tad off after cleaning until i fire a couple of fouling rounds through them. Every rifle is different so i' d experiment and find out for myself.
It has been my experience that many rifles do shoot a little differently from a clean, cold barrel, and then again, many don' t!! You need to fire yours with a clean cold barrel, and find out!! If it does shoot differently, then zero it with a clean, cold barrel, so the first shot hits where you want it to! This, according to Col. Townsend Whelen, is called the " sniper' s zero" , the idea being that it is the first shot that counts. For me this is very true, since I hunt with a Ruger No. 1 single-shot rifle.