I've spent way too much time agonizing over this. My only solace was I didn't have to specify a home defense/concealed carry handgun.
Browning BPS 12ga w/3.5" chamber - There is no smoother pump, and there never will be.
Winchester Wildcat .22LR - Because sometimes you want to be different, but classic.
Noveske GenIII with 18" 5.56x45NATO and 6.8SPC barrels - Light and lovely
Remington 673 .308Win. - Again, I'm different, but this is one I own and love.
Sako 85 Hunter .338Win. - Would love to learn how to shoot and reload this.