1006 S&W 10mm would be useful for both defense and hunting
(number 3 on the wish list)
I doubt anyone ever built a better quality , or more durable defensive pistol for the price

Id want a 100% reliable and accurate 22 lr with a decent Nikon 2x 7x 30mm scope
more than a few squirrels and
rabbits have fed hundreds of thousands of owners of that lever action 22lr.
if properly cleaned and well, maintained it will last well over any-ones life time

since I hand load Id like a very versatile CZ 458 LOTT bolt action, if you cast your own projectiles and hand load you could vary power levels from mild 44 mag to full on elephant stomping,458 LOTT

the 12 ga Benelli M1 super 90 is the best shotgun Ive ever handled, a damn impressive shotgun for hunting or home defense
(number 2 on the must have list)

if your limited to a single rifle, or firearm,
this would be my choice.
I'd want a match grade heavy barrel stainless m1a
with a nikon 5x-20x 30mm scope
keep in mind, many millions of dollars
and well in excess of 100 plus years of serious research and testing ,
were put into research
by hundreds of governments,
with each watching what the others did,
to provide their troops with the best and most effective rifles.
and the M1a is a civilian version of what is still (the M14)
considered a very good choice, so much so that current elite soldiers will frequently grab one if given a choice,
as it provides exceptional fire-power, range and accuracy,
in skilled, and experienced hands