I don' t always have a say so in the matter, but if I had a choice I would choose a shot quartering away behind the shoulder would be my perfeck shot, but I never go for the shoulder any way, always just behind the shoulder, this has proved successful for me for deer and elk as well as hogs down south. My deer and elk shots this year were shot just behind the shoulder into the lungs, neither of them went 50 yrds as their chest cavities were filled with blood as they may have drowned in their own blood. I like this shot because it has more room for error and a lot less waste of meat. I use a Remington model 700 30-06, spittin 180 gr coreloks. I would not hesitate to use this same set up on moose or bear.
Bobby