Actually when shooting 120 grain bullets from both the 260 Rem is flatter by 3 inches at 500 yards. I would go with the 260 Rem or a 270 Win, but I just don' t see much point to a 25-06 personally. I know some people swear by it and it is a good cartridge for deer, but the 260 Rem and 270 Win are much better in my opinion.