like all gun safety rule, if you THINK there is a chance of the bullet passing thru, or missing and landing in an unsafe zone( a 17 should go about 2 miles) DON"T take the shot
safety first as they say!
as for adjusting your aim when shooting up , I doubt is anything to worry about, as long as you know the distance and where the bullet lands at each distance you will shoot at, just work with that zero and should be fine IMO