If I could only pick one, it would be a Ruger M77 Hawkeye in 358 Win and would top it with a Leupold VX II (or 2) 3-7x33. What I like about the 358 is that it can shoot 180 grain bullets at near 30-06 velocities and 225 grain and 250 grain bullets will take pretty much anything in NA. If I could choose only one bullet it would probably be a 225 gr NP but, I could easily easily swayed to choose a 225 gr Sierra GameKing SPBT because they are really accurate in my Hawkeye.
My 358 Win has been my deer rifle of choice and my primary or backup rifle for the last few year's elk hunts. Sadly, this year was my last elk hunt. Age, along with back, knees and shoulder problems, finally made me realize that I'm no longer the spring chicken that I am (or was) in my mind's eye. Just means that I'll be doubling up on my deer, turkey and hog hunts.