Hard to argue that the 30-06 isn't one the best all-around caliber. But, for me my choice is the 358 Win. There is a good selection hunting bullets (from 180 grain to 250 grain) and the cartridge is very efficient. I've found that the 358 is really easy to reload and works well with a number of different powders (TAC, Varget, Win 748 and others). Like the 30-06, you can hunt most any game in NA. My 358 pretty much shoots everything I reload well and the fact that it is a short action rifle is a real plus for me.