Well RR, I have to agree and disagree a bit. While yes speed kills, bullet construction has so much to do with that. I myself hunted them with the .300WM as I stated and with 220gr bullets. The Interlock bullets are a fairly stout bullet and can handle the speeds of the .300WM pretty well. And it's a big old bullet making a big old hole and a whole lot of soup in between the ribs. Places you get shots on Moose are not often considered long range shots. Most would be pretty lucky to have a 300+ yard shot on one. But you also need to consider the bone density of a Moose compared to the little Eastern Whitetail you poke at. Not meaning any offense, just that there is around 1500+ pounds of difference. The rib bone of a Moose is pretty near what the shoulder of a Whitetail in bone density and thickness from your neck of the woods would be. It's not so much the speed you need to factor into the equation but bullet weight and construction.