The .308 calibers are always going to be the kings of going from light to heavy no doubt. I do prefer the 300 win mag over the 30-06 for more versatility but not everyone shoots longer range. The 300 win mag in the wrong gun fit will punish you. The 30-06 is cheaper to shoot and will do everything you want with in reason. The 30-06 has been a go to caliber for a lot of reasons but for a all around North American caliber it's probably #1.
Now going back to Flags post. If only shooting at reasonable ranges there is something about just knocking the crap out of animals with the 375 H&H. That's a whole other world of kinetic energy.