Unless you had your gun out in the rain or somehow it got some water/mud etc. there' s no need to totally disasemble and clean everything. It don' t hurt anything...it' s just not necessary.

A .22 usually has powder residue and maybe some lead fowling.....centerfire rifles are mostly fouled by copper.

I' m assuming you' re talking about centerfire rifles...

There' s no hard and fast rule to cleaning their barrels. Every barrel has it' s own needs and we all run different bullets through them. If you shoot a lot of Barnes, Failsafes, etc. you might want to clean after ten shots. If you have a Shilen barrel compared to a Shaw barrel there will be a difference in cleaning frequency.

I have a M-70 in .223 that has fired at least 300 rounds at prairie dogs without a rod in the barrel....and it keeps on killing them varmints. Other rifles want to be cleaned at least every fifty rounds. In the evening while the potatos are baking all the guns get the works with coppersolvent regardless of how much they are shot during the day.

If you notice accuracy falling off, it needs to be cleaned. If you look through the barrel and it' s the same color as the bullets you' re shooting, it needs to be cleaned.

A general rule of thumb might be to clean your hunting rifle after every box of ammo has been fired in it. You might want to clean it more often but there' s nothing that says to do so.

In short, there' s no answer to your question. It' s totally up to you.