It is possible that the unevenness is causing the noise, but unlikely. It is more likely causing a loss of speed. Try a string leech on the cable. It seems to make a huge difference, as I believe a lot of the vibration comes from there and not the string itself. Also, make sure all accessories are tight, including cable guard. Put a cable dampener on the cable guard as well. Shoot someone else' s bow, too. You might find that it just sounds loud to you, but it isn' t really any louder than anyone else' s.

Did the noise develop suddenly, or has it always been that way? If so, you may have something come loose or the string and cable have stretched and it is out of time.