What is your load? Barrel length? I have a scope on my Redhawk that's zeroed at 50 yards and to nail a deer or hog at 100 I hold about 3". If I remember correctly, the MPBR of the rifle configuration is right at 150 yards. So zero at 100 and from 0-150 yards you should be inside of the vitals with 150 being on the low side of the lungs. At 150, I'd try my best to stay off shoulder though and go for a clean lung shot. As I said earlier, at 150 it's starting to seriously run outta gas. The leverevolution bullet would still be going OKAY but I'd still stay off the shoulder. But from 0-around 130 the little .44mag rifles are some really good deer smackers. From 0-100 the pistols hold their own as well