I usually strive to take the "archery shot" regardless of weapon being used. In every target you can see where the lungs, heart and liver overlap. I refer to this as the "archery shot". Southern Mi offers a great deal of variety in deer sex and size. The "archery shot" would necessitate a different amount of energy needed between full expansion and pass-through on a broadsie small doe vs a 200lbs+ buck quartering towards. Simply, if I were to go for a bullet that will give me full expansion on the broadside archery shot, will it have enough energy when a quartering shot for a 200lbs monster is presented?
Accuracy is number 1 for hunting bullets. Then I want bullet construction and penetration to take any shot I may encounter on the animal I am hunting. Once I know that it will do those things, transfer as much energy as possible to the game animal.