I have shot deer with multiple calibers and grains from 80- 260. They all killed deer pretty well.... The most "bang flops" I've had though have been with remington accutip slugs... None have exited the deer, and all the deer either flopped over or took one or two more jumps and dropped over. I personally typically aim for a double lung. But on a few certain properties in urban areas that I've hunted in the past, I aim for a shoulder shot to drop them. Just depends on the situation. I don't know which is better. A complete pass through typically gives you a better blood trail though. And being able to track a hit deer is important.
-Jake