Last winter I bought my wife a 7mm08 in TC Venture. I used it this year deer hunting when my son adopted my .30-06 for the weekend.
I did get a shot at a running (wounded) buck and man that gun handled WONDERFULLY, came up quick, was right on target, I was impressed.
For take down, my wife took a 300+ lb mule deer at 176 yards and a 14 inch pronghorn at 120 yards, both down with one shot. I'm sold, it's a great gun!
We can't find ammo in Walmart like for my .30-06, but it's in basspro, cabelas and some other places. Bullet selection is a bit hard to find, but that varies where you live.