I shoot a 300 WM and have for quite sometime now. Agree that the .06 will do all that you ask of of it on most critters. One thing I know that when my .300 goes off deer drop. I hunt mostly in WV so extended range doesn't come into play for me, maybe 150 yes at most in these hills. I have a hard time finding bullets that don't destroy meat. Shoot then in the neck and it darn near decapitates them. I used to shoot an .06 but I prefer my 300.