I have shot a few with that slug setup and it hammers them. Like flags said through the heart lung area on a broadside shot almost always puts them down either immediately or in a short run. If dropping them is important like not wanting them to get off the property a shot through the shoulders drops them in one spot. It does ruin lots of meat though so the spot to aim is a personal choice. I don't advocate neck or head shots simply due to little room for error.