Hi super_hunt54,

I'll have to disagree.

Women, even petite women, can shoot large handguns.

It's all about penetration. This in one of many areas where 110 grain .38 caliber bullets would be a very poor choice.

I'll vehemently disagree about human tenacity. Human beings, absent a CNS hit, can take a whole lot of lead. My friend put 6 rounds from his duty .357 Mag revolver into the X ring of a very bad guy. A single round of 12 gauge 00 buck reduced him to property of the corner as evidence.

BTW, there is no such thing as a man stopper tactical handgun.

When in come to self-defense, bigger & heavier bullets are better.

Best of luck to you.