I'm cross dominant sorta. I'm naturally left handed but back in the dark ages when I was young, teachers and parents made us lefties do everything right handed. I became fairly ambidextrous that way. I am actually more comfortable shooting rifles right handed but can do it left handed almost as well. I am left eye dominant (strongly) so I shoot handgun lefty. As for handguns, one eye closed isn't too smart in a self defense situation so you have to go with your strengths in unison.