I have 2 .500 S&W's, one 4 inch one 8 inch. The 8 inch is scoped and of course longer so it's heavier. Shooting it isn't quite a "pleasure" but not to awful bad. The 4 inch on the other hand, is tantamount to holding a kicking, screaming, biting, thrashing 4 year old. But that 4 year old is awful mean on the business end
I would imagine that .300wm TC that Lone Wolf uses would be about the same!