You're right I don't know a lot about hunting. Which would be why I'm asking. I assumed people that frequented this sort of forum would be able to help. The only time I've used a gun was a .22 in college target competition. Never hunted anything.

To be more specific... The hunter in question is out on a deer hunt. Through some fantasy/twilight zone type transformation, he's brought to another universe and runs across a herd of animals more akin to buffalo. I'm guessing that a .22 would be a poor choice of weapon for an animal with that thick of a hide. I could be wrong.