It's been a number of years but I used to load some .375 winchester rounds for a friend that had a Marlin lever gun. If I recall correctly, those loads I had for him were not THAT much faster than the load you have worked up for your H&H. I'll have to drag out one of my old load data logs and see but I'm thinking I had him running at around 2500-2550 with that same bullet you have loaded. It sure laid waste to a deer. And no it didn't damage much meat around the shot. I saw him drop a fat doe at around 45 yards that looked like it was hit with a lightning bolt. Bang- flop!