WOW!! does that thing loose its punch fast. But the shot placement is the key. I have a friend that has killed deer for years with his .45 caliber Traditions Shenandoah (I think that is what model he has. His rifle is over thirty five years old). And he's never had a problem killing deer with it.
Now to the buckhorn sights. After years of those fat T/C sights, I found I really like the buckhorn sight. For some reason I can focus in them. But each find their own favorite sight (actually mine is a scope) and stick with that.