Interesting topic I am curious to see what other people post.

For me the most important characteristic is reliability: I have to be 100% certain that weapon is going to work and work in a big hurry. Carry comfort is also important for the reasons JeepKid wrote about. But for me reliability trumps comfort. And if you are wondering my primary CCW weapon is a Smith & Wesson "Chief's Special." Secondary to the Chief is a Kimber Solo.