Something to figure in your calculations. Near half speed, say around 20 MPH, a Bear or Hog is going to be covering 10 yards a second.

Just thinking out loud. Chances are the pucker factor is going to be high, chances of missing the first shot probable. And factor in handgun stopping power and it is likely to take more than one hit just to get it's attention.

I want something with low recoil or you may never get a second shot.

I want something I can shoot with one hand if I have to. Large caliber magnums are hard to shoot one handed and even slower to recover from recoil one handed.

The best handgun is likely to be different for each shooter.