A PRB is like a Powerbelt. What I mean is if you push them too fast they overexpand, and won't penetrate. That means no passthrough, and maybe no blood trail. The closer the shot. The worse it is.

No need to use 100gr 3F for a doe. I don't use that much for elk. Everybody talks about our forefathers using a PRB successfully. That's right they did. They didn't use heavy powder loads.

For deer all you need for a .50 is 70gr of 2F. It will pass through unless you're shooting beyond what a PRB should be shot. Even at 70gr it will expand just fine, but won't pancake.