My Endeavor encore in 50 caliber will out 105 gr. to 115 gr Blackhorn pretty close with Lehigh 250 gr, Shock Waves, and Gold dots all 250 gr. but when I go to the same bullet in 200 gr. it shoots 3 inches higher.
I tried some 140 and 135 grain loads with it and the poi was quite different but it grouped well at over 2300 fps.
With the 45 Prohunter it changes more for different powder loads and bullets.