One thing to consider is the size of the deer you are hunting. Do you plan on hunting 80 pound Coues deer or 300 pound Canadian giants? How about making your choice based on the whitetail subgroup you are hunting. Here are some suggestions:

Whitetail Subgroup____________Caliber Suggestions
Dakota________________________28/7mm/30/8mm/338/35
Northern Woodlands_____________28/7mm/30/8mm/338/35
Northwestern___________________28/7mm/30/8mm/338/35
South Central Plains________________25/26/6.5mm/270
Southeastern______________________25/26/6.5mm/270
Gulf Coast_________________________25/26/6.5mm/270
Seminole____________________________24/6mm
Coues______________________________24/6mm