My favorite firearm of all time is a Ruger Mark II stainless 22lr pistol, bagged plenty of squirrels with it over the years:
These Mark II's aren't available anymore, but their successor is just as good, with a few feature upgrades that a lot of people saw as improvements. I have a bunch of Mark I/II/III pistols, and one 22/45, really love the Ruger action.
I also have a Beretta NEOS, S&W 41, Colt Woodsman, and Browning Buckmark 22lr pistols, all very good pistols, some more expensive than others. The Buckmark and the Ruger Mark II's are my favorite (the latter taking top spot).
I'm also a big fan of the Ruger SP101 22LR double action as well.
If you're into something more powerful, the Taurus Tracker in 17HMR is a real treat as well.