I don't see why not. Pressure should be close to 26Kpsi with that load. You could always try a 54x45 Harvester and a Barnes 300gr SOCOM bullet....My 54-120 loves that combo with 110-120gr of BH209. There are LOTs of good 50cal bullets available if you just want to stick to 54x50s.

If im not mistaken Hunter offers a smoker kit that will upgrade to the SML barrel style plug.