Your post title was a bit misleading to me. But like some of the other posters stated any BH that gets through the vitals will kill a deer in no time. It looks at though the Toxics have more cutting surface and the design cuts a circular hole in the animal. This type of wound would allow for less plugging and an easier blood trail. As for my experience - the most lethal BH I've ever used was a 100 gr Magnus Stinger. I shot 6 deer with them and all died within sight in the wooded area I hunt. The only reason I switched is because they are not as strong as other BHs and a slight bend will cause them to fly erratically. I now use either Slick Trick Vipertricks or Rage Hypodermics depending on the bow I am using.