The challenge I make to myself is "one shot - one kill." As cliche as it can sound, it's about collecting all of my experience and knowledge into one little cup-and-core package and sending it downrange in whatever amount of time my target gives me to send it.
I'll take one shot. If I miss, it's "until we meet again" - which we sometimes do. And, every shot is followed up - when I was a teenager I thought I'd missed an animal, but checked anyway. Found blood, and not far off - the deer.