I don't hunt deer, but I do go after hogs. Some of the larger hogs (250 Lbs or so) are probably tougher than deer. I just use Hornady Interlocks, either 150 or 180 grain. The 150 grain bullets will go right through a 150# hog. The 180's typically pass through anything I can find to shoot. I've recovered a couple of the 150 grain SP bullets, they expand nicely and I have seen no reason to try anything more expensive.