To your question regarding the 300 vs the 250 gr bullets. My answer is twofold in that it depends on the bullet. They would have to be the same manf. / design for an honest answer. IMO lets say a 240 gr and 300 gr .429" XTP I don't think you would notice a major difference on a deer size animal. So what my selection would boil down to is which one will give me the better accuracy.