It really depends on what your comfortable with. I'm not comfortable with taking a shot over 40yds so I wont but others can and will. As long as your bow has the necessary power at that range and you can accurately shoot that distance your fine. My father shot a deer at 110 yards and has taken other animals at high distances. If a deer is watching you, don't shoot as it'll jump the string when it see's the movement but a comfortable deer generally isn't going to freak.