I've used Hornady Interlock bullets for years with great success in .243, .270, 7-08, and 30-06 for whitetails, mulies, pronghorn and black bear at ranges from literally point blank to over 400 yards. As several have said a premium bullet isn't necessary. What I've done that works for me is to visualize a ball in the deer's chest between the shoulders with the center just behind the shoulder. I aim for the center of that 'ball' no matter the angle. Putting the bullet in this location I've never lost an animal. And most that were broadside or quartering away were DRT.