what I do, is stay off the shoulder till the distance slows the bullet down enough to not fragment the bullet, the higher the velocity the greater the distance is that I do not shoulder shoot. behind the shoulder is a dead, easily tracked deer every time with anything.
I shoot a lot of high intensity cartridges, I've killed many deer with cup/core bullets in excess of 3500 fps, they kill deer "deader than raid" but destroy a lot of meat and make one helluva mess with center shoulder hits, increase the distance to 500 yards and that changes only because the bullet is moving slower and doesn't hit as hard.
the accubonds will do fine with any shot at 7/08 velocities on deer, the interlocks may fragment at close range from the '06, for wood hunting inside 200yards I always try to take a double lung shot, when I break out the long range rigs and the shot comes at 700 yards or farther I always hold either center shoulder or if quartering the point of aim is to break the offside shoulder
here in an exit from a whitetail shot with an accubond at 702 yards

hope I clarified my opinion
RR