I've killed plenty of game for consumption with all lead bullets and shot and have never worried about heavy metal poisoning on my end. Certainly not enough to swap to lead-free bullets for that reason.
I have shot a few boxes of the Barnes bullets only as an assessment as "an accurate bullet", not because of the lead-free attribute. I had good performance from the TTSX, but my state doesn't require lead-free bullets for some half-baked hippy conspiracy, and they weren't as accurate as other pills I tried against them, so I don't use them. Nothing wrong with them, smacked a couple piggies with them and they did fine, but they weren't as accurate in my rifles as other bullets, so I went the other way. They were very accurate, but they weren't the MOST accurate pills in my rifle, I have a cousin that shoots TTSX's exclusively, and they ARE the most accurate in his rifles - VERY accurate.