It took me awhile to find the combination that works for me. Here's a picture of my rear sight. A wide v sight. I use a TC fiber optic front sight. It's the smallest FO sight i've ever seen. Much smaller than the stock front sight.

I find it easy to drop that front FO sight into the middle of that rear sight pictured. Even when it's not in focus. The dark rear sight, and that glowing little front sight is easy to line up. Then it's just a matter of setting the front glowing front sight right under the target for a 6 o'clock hold. I'm amazed at how fast I can get it on the target, and be accurate with it. Even when nothing is in focus.